NRG1

Across TCGA patient cohorts, NRG1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,278 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NRG1-associated proteins across cancer lineages are CTNNA1, S100A2, and KRT5. Each is linked with NRG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NRG1-to-partner and partner-to-NRG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NRG1 versus CTNNA1 in COAD, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG1→partner) and Y-score (partner→NRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CTNNA1 →	+0.297	+0.299	.003	.005	3	4
LSCC	S100A2 →	+1.605	+0.992	<.001	.001	3	4
PDAC	KRT5 →	+1.590	+0.389	.001	.002	3	4
BRCA	COL17A1 →	+1.342	+0.729	<.001	<.001	3	4
LSCC	COL17A1_S174 →	+2.007	+0.904	<.001	.001	3	4
HNSC	AHNAK2_S260 →	+1.095	+1.031	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,278 associations by consensus.

NRG1 vs CTNNA1 — COAD

Explore this scatter interactively →