NRG1

Across TCGA patient cohorts, NRG1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRG1-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and ER-alpha_pS118. Each is linked with NRG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NRG1-to-partner and partner-to-NRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NRG1-low versus NRG1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG1→partner) and Y-score (partner→NRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.634	+2.321	.006	.035	3	4
UCEC	Caspase-7-cleavedD198 →	+0.420	+1.242	.009	.020	3	4
SKCM	ER-alpha_pS118 →	+0.119	+2.584	.009	.009	3	4
STAD	p90 RSK →	+0.244	+2.321	.009	.005	3	3
STAD	ER-alpha →	-0.166	-2.300	.009	.005	3	3
STAD	JNK_pT183_Y185 →	-0.125	-2.584	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Cyclin-B1 by NRG1 expression — LUAD

Explore this box plot interactively →