NRG1

Across TCGA cell cohorts, NRG1 mutation is significantly associated with the RNA expression of many other genes, with 701 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRG1-associated genes across cancer lineages are MSH4, C20orf173, and PRG3. Each is linked with NRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRG1-to-partner and partner-to-NRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by NRG1-low versus NRG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG1→partner) and Y-score (partner→NRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSH4 →	+0.192	+1.932	.002	.005	3	2
SKIN	C20orf173 →	+0.022	+3.632	<.001	.003	3	1
SKIN	PRG3 →	+0.016	+4.022	<.001	.006	3	1
SKIN	OR10H5 →	+0.011	+3.977	<.001	.001	3	1
SKIN	DSCAML1 →	+0.020	+3.345	<.001	.007	3	1
SKIN	KRTAP5-6 →	+0.047	+3.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 701 associations by consensus.

MSH4 by NRG1 expression — LARGE_INTESTINE

Explore this box plot interactively →