NREP

Across TCGA pan-cancer cohorts, NREP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NREP data layer compared with 27 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NREP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NREP expression acts as an unfavorable survival marker.

BRCA, SKCM, and COAD are the cancer types where NREP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.019	0.881	<.001	20	view →
SKCM	OS	Median	All	0.296	0.788	<.001	13	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
HNSC	OS	Median	All	0.183	0.660	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NREP–BRCA (DFS)

Open the BRCA breakdown →