NREP-AS1

Across TCGA pan-cancer cohorts, NREP-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated NREP-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher NREP-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NREP-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and ESCA show a favorable association.

THCA, KIRC, and THYM are the cancer types where NREP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	III,IV	0.906	0.975	<.001	72	view →
KIRC	OS	Tertile	All	0.501	0.671	<.001	56	view →
THYM	OS	Tertile	All	0.169	0.930	<.001	45	view →
STAD	OS	Tertile	IV	0.120	0.614	<.001	42	view →
TGCT	DFS	Tertile	II,III,IV	0.015	0.919	<.001	36	view →
BRCA	DFS	Tertile	All	0.365	0.545	<.001	30	view →
MESO	DFS	Tertile	III,IV	0.648	0.354	.019	27	view →
KIRP	OS	Tertile	III,IV	0.202	0.731	.001	21	view →
ESCA	DFS	Median	III,IV	0.605	0.363	.017	21	view →
UCS	OS	Tertile	All	0.304	0.613	.006	18	view →
LUAD	DFS	Tertile	IV	0.140	0.603	.021	18	view →
SARC	DFS	Quartile	All	0.357	0.559	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

NREP-AS1–THCA (OS)

Open the THCA breakdown →