NRDE2

Across TCGA patient cohorts, NRDE2 mutation is significantly associated with the RNA expression of many other genes, with 3,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRDE2-associated genes across cancer lineages are DVL2, ANKRD54P1, and GEMIN4. Each is linked with NRDE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRDE2-to-partner and partner-to-NRDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DVL2 grouped by NRDE2-low versus NRDE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRDE2→partner) and Y-score (partner→NRDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DVL2 →	+0.507	+4.269	<.001	<.001	3	3
LUAD	ANKRD54P1 →	+0.274	+3.817	<.001	.002	3	3
UCEC	GEMIN4 →	+0.447	+2.524	<.001	<.001	3	3
UCEC	SLX4 →	+0.566	+2.032	<.001	<.001	3	3
LUAD	SLC25A5P9 →	+0.035	+3.480	<.001	.005	3	3
SARC	RN7SKP59 →	+0.157	+5.380	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

DVL2 by NRDE2 expression — UCEC

Explore this box plot interactively →