NRDE2

Across TCGA patient cohorts, NRDE2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRDE2-associated genes across cancer lineages are C-Raf, PCNA, and Shc_pY317. Each is linked with NRDE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRDE2-to-partner and partner-to-NRDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NRDE2-low versus NRDE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRDE2→partner) and Y-score (partner→NRDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.139	+1.652	.003	.006	3	3
UCEC	PCNA →	+0.310	+2.263	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.143	-1.392	.004	.019	3	2
UCEC	Di-Ras3 →	-0.148	-2.687	.002	.005	3	2
UCEC	14-3-3_beta →	-0.111	-2.880	<.001	.001	3	1
UCEC	eIF4E →	+0.172	+1.392	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

C-Raf by NRDE2 expression — UCEC

Explore this box plot interactively →