NRDE2

Across TCGA cell cohorts, NRDE2 mutation is significantly associated with the RNA expression of many other genes, with 268 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRDE2-associated genes across cancer lineages are DPRX, ARMH2, and OLIG3. Each is linked with NRDE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRDE2-to-partner and partner-to-NRDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by NRDE2-low versus NRDE2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRDE2→partner) and Y-score (partner→NRDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DPRX →	+0.080	+3.339	<.001	.004	3	2
BLOOD_Lymphoma	ARMH2 →	+0.067	+2.984	.009	.007	3	2
BLOOD_Leukemia	OLIG3 →	+0.529	+4.409	<.001	.005	3	2
LARGE_INTESTINE	KIAA1328 →	+0.500	+2.389	.001	.006	3	2
PANCREAS	ART1 →	+0.027	+4.011	.001	.009	3	1
PANCREAS	CNPY1 →	+0.067	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 268 associations by consensus.

DPRX by NRDE2 expression — OVARY

Explore this box plot interactively →