NRDC

Across TCGA pan-cancer cohorts, NRDC Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated NRDC data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NRDC Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRDC expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

KIRC, UCEC, and BLCA are the cancer types where NRDC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.133	0.796	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.942	0.300	.005	24	view →
BLCA	DFS	Median	III,IV	0.750	0.284	.012	22	view →
ESCA	DFS	Median	II,III,IV	0.162	0.525	.011	18	view →
LIHC	DFS	Median	II,III,IV	0.068	0.431	<.001	18	view →
HNSC	DFS	Median	III,IV	0.165	0.569	.032	15	view →
LGG	DFS	Median	All	0.083	0.826	<.001	6	view →
CESC	DFS	Median	II,III,IV	0.086	0.497	.042	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SKCM	DFS	Median	II,III,IV	0.125	0.713	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

NRDC–KIRC (DFS)

Open the KIRC breakdown →