NRDC

Across TCGA pan-cancer cohorts, NRDC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NRDC data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NRDC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRDC expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where NRDC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.226	0.682	.001	39	view →
LSCC	DFS	Tertile	All	1.000	0.384	.004	16	view →
PDAC	OS	Quartile	III,IV	0.210	0.486	.016	7	view →
HNSC	DFS	Tertile	III,IV	0.911	1.000	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NRDC–CCRCC (DFS)

Open the CCRCC breakdown →