NRBP1

Across TCGA pan-cancer cohorts, NRBP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NRBP1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRBP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NRBP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, COAD, and PDAC are the cancer types where NRBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.890	0.679	.005	26	view →
COAD	DFS	Median	All	0.885	1.000	.018	24	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	12	view →
LUAD	DFS	Tertile	II,III,IV	0.767	0.402	.011	11	view →
CCRCC	DFS	Median	All	0.865	0.967	.009	6	view →
UCEC	OS	Median	All	0.909	0.991	.030	2	view →
GBM	DFS	Tertile	All	0.261	0.502	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NRBP1–HNSC (DFS)

Open the HNSC breakdown →