NRBP1

Across TCGA patient cohorts, NRBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,458 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRBP1-associated genes across cancer lineages are RNU4-84P, TRAJ53, and RNA5SP198. Each is linked with NRBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRBP1-to-partner and partner-to-NRBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-84P grouped by NRBP1-low versus NRBP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRBP1→partner) and Y-score (partner→NRBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU4-84P →	+0.269	+5.317	.009	.006	3	2
BRCA	TRAJ53 →	+0.777	+5.148	<.001	.008	3	2
CESC	RNA5SP198 →	+0.305	+5.144	<.001	.003	3	2
UCEC	CENPU →	+0.870	+4.202	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.534	+3.332	.002	.005	3	2
UCEC	HAUS1 →	+0.620	+3.119	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,458 associations by consensus.

RNU4-84P by NRBP1 expression — BRCA

Explore this box plot interactively →