NRBF2

Across TCGA pan-cancer cohorts, NRBF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NRBF2 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRBF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NRBF2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where NRBF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.756	0.535	.005	23	view →
CCRCC	DFS	Quartile	III,IV	0.227	0.761	<.001	16	view →
PDAC	DFS	Tertile	IV	0.199	0.715	.024	9	view →
GBM	DFS	Tertile	All	0.514	0.252	.022	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NRBF2–HNSC (DFS)

Open the HNSC breakdown →