NRBF2

Across TCGA patient cohorts, NRBF2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRBF2-associated genes across cancer lineages are Shc_pY317, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with NRBF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRBF2-to-partner and partner-to-NRBF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by NRBF2-low versus NRBF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRBF2→partner) and Y-score (partner→NRBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.180	-1.678	.001	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.820	+3.720	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.112	-3.558	.003	.002	3	1
UCEC	EGFR_pY1068 →	-0.306	-1.678	.001	.023	3	1
UCEC	A-Raf_pS299 →	-0.145	-3.169	.001	.018	3	1
UCEC	ERK2 →	+0.209	+1.678	.004	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Shc_pY317 by NRBF2 expression — UCEC

Explore this box plot interactively →