NRBF2

Across TCGA cell cohorts, NRBF2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRBF2-associated genes across cancer lineages are VAX1, OR2T8, and USP17L7. Each is linked with NRBF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRBF2-to-partner and partner-to-NRBF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAX1 grouped by NRBF2-low versus NRBF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRBF2→partner) and Y-score (partner→NRBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VAX1 →	+0.632	+3.519	.001	.007	3	1
LARGE_INTESTINE	OR2T8 →	+0.165	+3.584	<.001	.004	3	1
LARGE_INTESTINE	USP17L7 →	+0.061	+3.333	<.001	.009	3	1
LARGE_INTESTINE	NEXMIF →	+0.243	+3.518	<.001	.001	3	1
LARGE_INTESTINE	GSC2 →	+0.099	+3.103	<.001	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.045	+3.187	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VAX1 by NRBF2 expression — LARGE_INTESTINE

Explore this box plot interactively →