NRAV

Across TCGA pan-cancer cohorts, NRAV RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NRAV’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NRAV RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRAV is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where NRAV tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRAV RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.501	<.001	12	view →
KICH	Female	II,III,IV	−2.322	<.001	10	view →
THCA	Male	IV	−0.866	<.001	10	view →
BLCA	All	All	+0.688	<.001	10	view →
LIHC	Female	II,III,IV	+1.249	<.001	9	view →
COAD	Female	II,III,IV	+0.761	<.001	9	view →
KIRP	Male	II,III,IV	+0.684	<.001	9	view →
BRCA	All	III,IV	+0.821	<.001	6	view →
CHOL	Female	All	+3.466	<.001	5	view →
STAD	All	II,III,IV	+0.566	.002	5	view →
READ	All	III,IV	+1.090	.039	2	view →
UCEC	All	III,IV	+0.988	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NRAV–KIRC

Open the KIRC breakdown →