Across TCGA patient cohorts, NRAS mutation is significantly associated with the RNA expression of many other genes, with 10,000 significant associations in total. THCA shows the largest number of these associations.

The most reproducible NRAS-associated genes across cancer lineages are PHKB, HSD17B4, and MX1. Each is linked with NRAS in more than 3 cancer types. Because this analysis shows association rather than direction, both NRAS-to-partner and partner-to-NRAS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRAS→partner) and Y-score (partner→NRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHKB →	+0.446	+1.930	.002	.009	3	4
COAD	HSD17B4 →	+0.418	+3.209	.005	.009	3	4
THCA	MX1 →	-0.745	-2.453	<.001	<.001	3	4
SKCM	NAALADL1 →	-0.372	-0.810	.001	<.001	3	4
SKCM	DLEU1 →	+0.243	+0.795	<.001	<.001	3	4
THCA	LYNX1 →	-0.907	-2.442	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,000 associations by consensus.

Exploration

NRAS survival (RNA) · tumor vs normal (RNA) · all NRAS data types