NRAS

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NRAS mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. THCA shows the largest number of these associations.

The most reproducible NRAS-associated genes across cancer lineages are Bim, YB-1_pS102, and JNK2. Each is linked with NRAS in more than 2 cancer types. Because this analysis shows association rather than direction, both NRAS-to-partner and partner-to-NRAS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRAS→partner) and Y-score (partner→NRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECBim →-0.252-2.807.007.00333
THCAYB-1_pS102 →+0.466+1.750<.001.04933
READJNK2 →+0.222+2.879.015.02732
READAMPK_alpha →+0.331+3.000.002.03232
THCAFibronectin →-2.969-3.571<.001.00232
COADTuberin →+0.367+3.708.006<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

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