NR5A2

Across TCGA patient cohorts, NR5A2 mutation is significantly associated with the RNA expression of many other genes, with 5,755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR5A2-associated genes across cancer lineages are AATF, RNA5SP412, and CENPO. Each is linked with NR5A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR5A2-to-partner and partner-to-NR5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AATF grouped by NR5A2-low versus NR5A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR5A2→partner) and Y-score (partner→NR5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AATF →	+0.346	+1.736	.001	<.001	3	3
UCEC	RNA5SP412 →	+0.448	+1.619	<.001	.002	3	3
LUAD	CENPO →	+0.653	+3.217	.003	.009	3	3
CESC	LINC00355 →	+0.807	+3.304	<.001	.008	3	3
UCEC	SKA1 →	+0.743	+2.470	<.001	<.001	3	3
UCEC	SUPV3L1 →	+0.390	+2.470	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,755 associations by consensus.

AATF by NR5A2 expression — UCEC

Explore this box plot interactively →