NR5A2

Across TCGA cell cohorts, NR5A2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NR5A2-associated genes across cancer lineages are DNAH8, OR2T1, and CETN1. Each is linked with NR5A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR5A2-to-partner and partner-to-NR5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAH8 grouped by NR5A2-low versus NR5A2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR5A2→partner) and Y-score (partner→NR5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNAH8 →	+0.369	+4.054	<.001	.004	3	1
SKIN	OR2T1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	CETN1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OR10J5 →	+0.016	+4.437	<.001	.004	3	1
SKIN	TDRD15 →	+0.204	+3.793	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR1E2 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

DNAH8 by NR5A2 expression — SKIN

Explore this box plot interactively →