NR5A1

Across TCGA pan-cancer cohorts, NR5A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NR5A1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NR5A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NR5A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where NR5A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.834	0.259	.005	14	view →
LSCC	DFS	Median	II,III,IV	1.000	0.330	.006	10	view →
UCEC	OS	Median	All	0.881	1.000	.043	2	view →
GBM	OS	Median	All	0.995	0.732	.002	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NR5A1–LUAD (OS)

Open the LUAD breakdown →