NR5A1

Across TCGA cell cohorts, NR5A1 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR5A1-associated genes across cancer lineages are SH3GL2, PTGES3, and ATPAF1. Each is linked with NR5A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR5A1-to-partner and partner-to-NR5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by NR5A1-low versus NR5A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR5A1→partner) and Y-score (partner→NR5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.180	+3.465	.001	.002	3	1
LARGE_INTESTINE	PTGES3 →	+0.433	+3.212	.001	.006	3	1
LARGE_INTESTINE	ATPAF1 →	+0.745	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ATP5F1E →	-0.832	-3.169	<.001	.009	3	1
LARGE_INTESTINE	ECHS1 →	+0.681	+3.212	.001	.006	3	1
LARGE_INTESTINE	ATP6V1C2 →	+1.399	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

SH3GL2 by NR5A1 expression — LARGE_INTESTINE

Explore this box plot interactively →