NR4A2

Across TCGA patient cohorts, NR4A2 mutation is significantly associated with the RNA expression of many other genes, with 6,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR4A2-associated genes across cancer lineages are GINS3, SNRNP25, and H2AZ1. Each is linked with NR4A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NR4A2-to-partner and partner-to-NR4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS3 grouped by NR4A2-low versus NR4A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A2→partner) and Y-score (partner→NR4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.702	+2.150	<.001	<.001	3	4
UCEC	SNRNP25 →	+0.618	+2.699	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.862	+3.769	<.001	<.001	3	3
UCEC	PTTG1 →	+0.761	+1.722	<.001	<.001	3	3
STAD	PCBD1 →	+0.521	+3.384	.006	.004	3	3
UCEC	TK1 →	+0.601	+1.938	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,575 associations by consensus.

GINS3 by NR4A2 expression — UCEC

Explore this box plot interactively →