NR4A2

Across TCGA cell cohorts, NR4A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,694 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NR4A2-associated GO terms across cancer lineages are Response to corticotropin-releasing hormone, Cellular response to corticotropin-releasing hormone stimulus, and Regulation of alpha-beta T cell activation. Each is linked with NR4A2 in more than 11 cancer types. Because this analysis shows association rather than direction, both NR4A2-to-partner and partner-to-NR4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to corticotropin-releasing hormone grouped by NR4A2-low versus NR4A2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A2→partner) and Y-score (partner→NR4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Response to corticotropin-releasing hormone →	+1.576	+2.163	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Cellular response to corticotropin-releasing hormone stimulus →	+1.511	+2.163	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of alpha-beta T cell activation →	+0.059	+0.872	<.001	<.001	3	9
BLOOD_Lymphoma	Regulation of intracellular mRNA localization →	+0.081	+0.766	<.001	.003	3	8
STOMACH	Regulation of appetite →	+0.144	+1.752	.006	.006	3	8
UPPER_AERODIGESTIVE_TRACT	GDF15-GFRAL signaling pathway →	+0.721	+0.454	.003	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

Response to corticotropin-releasing hormone by NR4A2 expression — LUNG_NSCLC_LUAD

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