NR4A2

Across TCGA cell cohorts, NR4A2 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR4A2-associated genes across cancer lineages are HTR1D, TESK2, and GCAT. Each is linked with NR4A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR4A2-to-partner and partner-to-NR4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1D grouped by NR4A2-low versus NR4A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A2→partner) and Y-score (partner→NR4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTR1D →	+1.203	+2.502	<.001	.005	3	2
LARGE_INTESTINE	TESK2 →	+0.675	+3.628	.002	<.001	3	2
LARGE_INTESTINE	GCAT →	+1.403	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.553	+3.459	.002	.001	3	1
LARGE_INTESTINE	ST13 →	+0.506	+3.169	.002	.009	3	1
LARGE_INTESTINE	TRMU →	+0.565	+2.502	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

HTR1D by NR4A2 expression — LARGE_INTESTINE

Explore this box plot interactively →