NR4A1

Across TCGA patient cohorts, NR4A1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR4A1-associated genes across cancer lineages are ERK2, MSH2, and Myosin-IIa_pS1943. Each is linked with NR4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR4A1-to-partner and partner-to-NR4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NR4A1-low versus NR4A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A1→partner) and Y-score (partner→NR4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.180	+3.321	.038	.009	3	1
UCEC	MSH2 →	-0.272	-2.973	.008	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.191	+3.169	.040	.019	3	1
UCEC	p62 Lck ligand →	+0.300	+3.169	.041	.018	3	1
UCEC	p70-S6K →	+0.199	+3.189	.021	.010	3	1
UCEC	p90 RSK →	+0.226	+2.331	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by NR4A1 expression — UCEC

Explore this box plot interactively →