NR4A1

Across TCGA cell cohorts, NR4A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,516 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NR4A1-associated GO terms across cancer lineages are Cellular response to corticotropin-releasing hormone stimulus, Response to corticotropin-releasing hormone, and Regulation of mRNA catabolic process. Each is linked with NR4A1 in more than 18 cancer types. Because this analysis shows association rather than direction, both NR4A1-to-partner and partner-to-NR4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to corticotropin-releasing hormone stimulus grouped by NR4A1-low versus NR4A1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A1→partner) and Y-score (partner→NR4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Cellular response to corticotropin-releasing hormone stimulus →	+1.733	+2.741	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Response to corticotropin-releasing hormone →	+1.808	+2.741	<.001	<.001	3	19
OESOPHAGUS	Regulation of mRNA catabolic process →	+0.063	+2.713	.002	<.001	3	11
LUNG_SCLC	Detection of lipopolysaccharide →	+0.591	+1.601	.002	<.001	3	11
LUNG_NSCLC_LUSC	Integrin-mediated signaling pathway →	-0.180	-1.955	<.001	.001	3	10
BLOOD_Lymphoma	Positive regulation of mRNA catabolic process →	+0.063	+2.114	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,516 associations by consensus.

Cellular response to corticotropin-releasing hormone stimulus by NR4A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →