NR3C2

Across TCGA patient cohorts, NR3C2 mutation is significantly associated with the RNA expression of many other genes, with 6,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR3C2-associated genes across cancer lineages are MSANTD3, XPNPEP1, and RAD23B. Each is linked with NR3C2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NR3C2-to-partner and partner-to-NR3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSANTD3 grouped by NR3C2-low versus NR3C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C2→partner) and Y-score (partner→NR3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSANTD3 →	+0.676	+3.296	<.001	<.001	3	4
UCEC	XPNPEP1 →	+0.530	+1.722	<.001	<.001	3	4
UCEC	RAD23B →	+0.543	+1.722	<.001	<.001	3	4
UCEC	CCNA2 →	+0.892	+2.936	<.001	<.001	3	4
UCEC	DLAT →	+0.685	+2.362	<.001	<.001	3	3
UCEC	NCAPD3 →	+0.666	+1.551	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,364 associations by consensus.

MSANTD3 by NR3C2 expression — UCEC

Explore this box plot interactively →