NR3C2

Across TCGA patient cohorts, NR3C2 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR3C2-associated genes across cancer lineages are Cyclin-E2, 4E-BP1, and PCNA. Each is linked with NR3C2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NR3C2-to-partner and partner-to-NR3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by NR3C2-low versus NR3C2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C2→partner) and Y-score (partner→NR3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.208	+2.828	.001	.033	3	4
COAD	4E-BP1 →	+0.322	+3.008	.004	.019	3	3
COAD	PCNA →	+0.267	+3.008	.037	.019	3	3
SKCM	PKC-b-II_pS660 →	-0.439	-3.169	<.001	.017	3	3
SKCM	Smad4 →	+0.125	+2.000	.013	.031	2	4
COAD	c-Met_pY1235 →	+0.230	+3.042	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Cyclin-E2 by NR3C2 expression — STAD

Explore this box plot interactively →