NR3C2

Across TCGA cell cohorts, NR3C2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,384 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NR3C2-associated GO terms across cancer lineages are Cellular response to sterol depletion, SREBP signaling pathway, and Negative regulation of intracellular transport. Each is linked with NR3C2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NR3C2-to-partner and partner-to-NR3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to sterol depletion grouped by NR3C2-low versus NR3C2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C2→partner) and Y-score (partner→NR3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Cellular response to sterol depletion →	+0.126	+0.351	.002	.003	2	8
KIDNEY	SREBP signaling pathway →	+0.137	+0.351	.002	.003	2	7
CNS	Negative regulation of intracellular transport →	+0.050	+0.538	.008	.008	2	7
SOFT_TISSUE	Golgi vesicle transport →	+0.040	+0.620	.004	.006	2	7
SOFT_TISSUE	Regulation of presynapse organization →	-0.137	-0.488	<.001	.001	3	6
BREAST	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.058	+0.825	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,384 associations by consensus.

Cellular response to sterol depletion by NR3C2 expression — KIDNEY

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