NR3C2

Across TCGA cell cohorts, NR3C2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR3C2-associated genes across cancer lineages are OR1L3, OR1J2, and IZUMO3. Each is linked with NR3C2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR3C2-to-partner and partner-to-NR3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by NR3C2-low versus NR3C2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C2→partner) and Y-score (partner→NR3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L3 →	+0.023	+2.859	.008	.008	3	3
CNS	OR1J2 →	+0.040	+4.472	<.001	.004	3	2
BLOOD_Leukemia	IZUMO3 →	+0.054	+4.969	<.001	.003	3	2
OVARY	FAM9B →	+0.312	+3.459	<.001	.008	3	1
OVARY	CCDC60 →	+0.037	+3.058	.003	.004	3	1
OVARY	DMRTC1 →	+0.028	+2.974	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR1L3 by NR3C2 expression — OVARY

Explore this box plot interactively →