NR3C1

Across TCGA pan-cancer cohorts, NR3C1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NR3C1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NR3C1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NR3C1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where NR3C1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.739	0.948	<.001	35	view →
LUAD	DFS	Tertile	III,IV	0.246	0.635	.019	6	view →
GBM	OS	Quartile	All	0.739	0.307	.019	4	view →
HNSC	DFS	Tertile	II,III,IV	0.528	0.711	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NR3C1–CCRCC (OS)

Open the CCRCC breakdown →