NR3C1

Across TCGA patient cohorts, NR3C1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR3C1-associated genes across cancer lineages are ASNS, ATM, and JNK_pT183_Y185. Each is linked with NR3C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR3C1-to-partner and partner-to-NR3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NR3C1-low versus NR3C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C1→partner) and Y-score (partner→NR3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.382	+1.874	<.001	.002	3	3
UCEC	ATM →	-0.494	-1.652	<.001	.005	3	3
UCEC	JNK_pT183_Y185 →	-0.132	-1.662	.006	.010	3	2
UCEC	mTOR_pS2448 →	-0.102	-1.489	.019	.025	3	2
UCEC	Notch1 →	+0.124	+1.598	.002	.009	3	2
UCEC	Rad50 →	-0.154	-1.295	.029	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by NR3C1 expression — UCEC

Explore this box plot interactively →