NR2F6

Across TCGA patient cohorts, NR2F6 mutation is significantly associated with the RNA expression of many other genes, with 352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2F6-associated genes across cancer lineages are RAD17, WHAMM, and NPTN. Each is linked with NR2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2F6-to-partner and partner-to-NR2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD17 grouped by NR2F6-low versus NR2F6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2F6→partner) and Y-score (partner→NR2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD17 →	+0.576	+3.227	.003	.009	3	1
UCEC	WHAMM →	+0.535	+3.386	<.001	.004	3	1
UCEC	NPTN →	+0.603	+3.202	.009	.009	3	1
UCEC	AMFR →	+0.588	+3.502	.007	.002	3	1
UCEC	ZER1 →	+0.440	+3.370	.003	.004	3	1
UCEC	NOL9 →	+0.546	+3.513	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

RAD17 by NR2F6 expression — UCEC

Explore this box plot interactively →