NR2F6

Across TCGA patient cohorts, NR2F6 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2F6-associated genes across cancer lineages are VHL, Ku80, and Smad1. Each is linked with NR2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2F6-to-partner and partner-to-NR2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by NR2F6-low versus NR2F6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2F6→partner) and Y-score (partner→NR2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.007	-3.000	.010	.037	3	1
UCEC	Ku80 →	+0.277	+3.013	.043	.019	1	1
UCEC	Smad1 →	+0.186	+3.000	.040	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

VHL by NR2F6 expression — UCEC

Explore this box plot interactively →