NR2F6

Across TCGA cell cohorts, NR2F6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR2F6-associated genes across cancer lineages are GFRA4, HDGFL1, and KNCN. Each is linked with NR2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2F6-to-partner and partner-to-NR2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by NR2F6-low versus NR2F6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2F6→partner) and Y-score (partner→NR2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	2
OVARY	HDGFL1 →	+0.505	+3.938	.009	.005	3	1
OVARY	KNCN →	+0.029	+3.700	.001	.005	3	1
OVARY	SLC36A2 →	+0.174	+4.169	<.001	.007	3	1
OVARY	GAGE12H →	+0.321	+3.990	<.001	.003	3	1
OVARY	CCDC195 →	+0.149	+3.938	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GFRA4 by NR2F6 expression — BLOOD_Leukemia

Explore this box plot interactively →