NR2F1

Across TCGA cell cohorts, NR2F1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR2F1-associated genes across cancer lineages are OR4D10, CCL16, and AMHR2. Each is linked with NR2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2F1-to-partner and partner-to-NR2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D10 grouped by NR2F1-low versus NR2F1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2F1→partner) and Y-score (partner→NR2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4D10 →	+0.039	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	CCL16 →	+0.030	+5.266	<.001	.001	3	1
LARGE_INTESTINE	AMHR2 →	+0.283	+3.285	.004	.007	3	1
LARGE_INTESTINE	BRDT →	+0.100	+3.169	<.001	.001	3	1
LARGE_INTESTINE	RASGEF1C →	+0.206	+3.555	.006	.003	3	1
LARGE_INTESTINE	PROK2 →	+0.082	+2.841	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR4D10 by NR2F1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →