NR2E3

Across TCGA patient cohorts, NR2E3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2E3-associated genes across cancer lineages are MEK1, Notch1, and eEF2. Each is linked with NR2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2E3-to-partner and partner-to-NR2E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NR2E3-low versus NR2E3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2E3→partner) and Y-score (partner→NR2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.333	+2.700	.027	.006	3	2
UCEC	Notch1 →	+0.143	+1.807	.013	.027	3	2
UCEC	eEF2 →	+0.304	+1.807	.039	.027	3	1
UCEC	EGFR_pY1068 →	-0.343	-2.321	<.001	.006	3	1
UCEC	A-Raf_pS299 →	-0.127	-1.807	.009	.027	3	1
UCEC	ERK2 →	+0.214	+1.807	.006	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MEK1 by NR2E3 expression — UCEC

Explore this box plot interactively →