NR2E1

Across TCGA patient cohorts, NR2E1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2E1-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with NR2E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2E1-to-partner and partner-to-NR2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NR2E1-low versus NR2E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2E1→partner) and Y-score (partner→NR2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.161	+1.514	.014	.015	3	2
UCEC	JNK2 →	+0.251	+2.137	<.001	.001	3	2
UCEC	MEK1 →	+0.301	+2.000	.015	.009	3	2
UCEC	Notch1 →	+0.127	+1.807	.008	.004	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.325	-1.501	.033	.015	3	2
UCEC	Tuberin →	+0.279	+2.459	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ERK2 by NR2E1 expression — UCEC

Explore this box plot interactively →