NR2E1

Across TCGA cell cohorts, NR2E1 mutation is significantly associated with the RNA expression of many other genes, with 527 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR2E1-associated genes across cancer lineages are TEX26, GFRAL, and GCAT. Each is linked with NR2E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2E1-to-partner and partner-to-NR2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX26 grouped by NR2E1-low versus NR2E1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2E1→partner) and Y-score (partner→NR2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TEX26 →	+0.025	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	GFRAL →	+0.013	+5.662	<.001	.002	3	1
LARGE_INTESTINE	GCAT →	+1.431	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.791	+3.330	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.820	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ADNP2 →	+0.833	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 527 associations by consensus.

TEX26 by NR2E1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →