NR2C2

Across TCGA pan-cancer cohorts, NR2C2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NR2C2 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NR2C2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NR2C2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where NR2C2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	22	view →
LUAD	DFS	Median	All	0.758	0.467	.002	21	view →
HNSC	DFS	Median	IV	0.856	0.675	.023	9	view →
PDAC	DFS	Tertile	II,III,IV	0.287	0.470	.016	8	view →
CCRCC	OS	Tertile	All	0.920	1.000	.040	1	view →
LSCC	OS	Quartile	All	0.925	0.805	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NR2C2–UCEC (OS)

Open the UCEC breakdown →