NR2C2

Across TCGA patient cohorts, NR2C2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2C2-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Src_pY527. Each is linked with NR2C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2C2-to-partner and partner-to-NR2C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NR2C2-low versus NR2C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2C2→partner) and Y-score (partner→NR2C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.347	-2.523	<.001	<.001	3	2
UCEC	JNK2 →	+0.235	+2.137	<.001	.001	3	2
UCEC	Src_pY527 →	-0.362	-2.311	.013	.005	3	2
UCEC	ATM →	-0.580	-3.893	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.598	+1.604	.003	.021	3	2
UCEC	eEF2 →	+0.326	+2.000	.007	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

EGFR_pY1068 by NR2C2 expression — UCEC

Explore this box plot interactively →