Across TCGA pan-cancer cohorts, NR1H5P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NR1H5P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where NR1H5P RNA is repressed in tumor relative to normal tissue. In most cancer types NR1H5P is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where NR1H5P tumor–normal differential expression is most reproducible.