NR1H3

Across TCGA pan-cancer cohorts, NR1H3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NR1H3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NR1H3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NR1H3 expression acts as an unfavorable survival marker.

CESC, ACC, and BLCA are the cancer types where NR1H3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
ACC	OS	Median	All	0.268	0.802	.010	12	view →
BLCA	DFS	Median	III,IV	0.078	0.489	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	OS	Median	All	0.407	0.799	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NR1H3–CESC (OS)

Open the CESC breakdown →