NR1H2

Across TCGA patient cohorts, NR1H2 mutation is significantly associated with the RNA expression of many other genes, with 2,400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1H2-associated genes across cancer lineages are RPL32P17, LYZL1, and RNA5SP369. Each is linked with NR1H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H2-to-partner and partner-to-NR1H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P17 grouped by NR1H2-low versus NR1H2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H2→partner) and Y-score (partner→NR1H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL32P17 →	+0.135	+4.243	.004	.009	3	2
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	2
CESC	RNA5SP369 →	+0.424	+5.539	<.001	.004	3	2
CESC	DNAJA1P1 →	+0.053	+5.306	<.001	.006	3	2
CESC	LINC01034 →	+0.211	+5.010	<.001	.009	3	2
UCEC	TRMU →	+0.516	+3.839	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,400 associations by consensus.

RPL32P17 by NR1H2 expression — BRCA

Explore this box plot interactively →