NR1H2

Across TCGA patient cohorts, NR1H2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1H2-associated genes across cancer lineages are p90 RSK, PCNA, and PDCD4. Each is linked with NR1H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H2-to-partner and partner-to-NR1H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by NR1H2-low versus NR1H2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H2→partner) and Y-score (partner→NR1H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.184	+2.999	.019	.035	3	2
UCEC	PCNA →	+0.237	+2.321	.007	.033	3	2
UCEC	PDCD4 →	-0.477	-1.807	.014	.027	3	2
UCEC	Rictor_pT1135 →	-0.102	-2.321	.016	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.695	+3.169	.004	.018	3	2
UCEC	FoxM1 →	+0.247	+3.331	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p90 RSK by NR1H2 expression — UCEC

Explore this box plot interactively →