NR1H2

Across TCGA cell cohorts, NR1H2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR1H2-associated genes across cancer lineages are LRIT1, OPN1MW2, and KRTAP10-1. Each is linked with NR1H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H2-to-partner and partner-to-NR1H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by NR1H2-low versus NR1H2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H2→partner) and Y-score (partner→NR1H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRIT1 →	+0.016	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OPN1MW2 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP10-1 →	+0.029	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CTXND2 →	+0.085	+4.867	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	YIPF7 →	+0.073	+3.722	<.001	.007	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

LRIT1 by NR1H2 expression — BLOOD_Lymphoma

Explore this box plot interactively →