NR1D2

Across TCGA patient cohorts, NR1D2 mutation is significantly associated with the RNA expression of many other genes, with 3,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1D2-associated genes across cancer lineages are MED28P4, TUBAP1, and RBM14. Each is linked with NR1D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1D2-to-partner and partner-to-NR1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED28P4 grouped by NR1D2-low versus NR1D2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D2→partner) and Y-score (partner→NR1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MED28P4 →	+0.394	+5.039	<.001	.008	3	2
SKCM	TUBAP1 →	+0.038	+2.963	.005	<.001	3	2
SKCM	RBM14 →	+0.454	+3.392	.001	.004	3	2
SKCM	RPL34P22 →	+0.197	+4.279	.006	<.001	3	2
UCEC	CASTOR2 →	+0.913	+3.119	<.001	<.001	3	2
COAD	OR5D3P →	+0.084	+5.917	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,385 associations by consensus.

MED28P4 by NR1D2 expression — READ

Explore this box plot interactively →