NR1D2

Across TCGA patient cohorts, NR1D2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1D2-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and Ku80. Each is linked with NR1D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR1D2-to-partner and partner-to-NR1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NR1D2-low versus NR1D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D2→partner) and Y-score (partner→NR1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.698	+2.189	.009	.034	3	3
UCEC	JNK_pT183_Y185 →	-0.191	-1.986	.012	.032	3	2
UCEC	Ku80 →	+0.315	+2.013	.003	.018	3	1
UCEC	p21 →	+0.198	+3.169	.022	.019	3	1
UCEC	PDK1_pS241 →	+0.189	+3.321	.013	.010	3	1
UCEC	PRAS40_pT246 →	+0.155	+3.000	.045	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by NR1D2 expression — UCEC

Explore this box plot interactively →