NR0B2

Across TCGA pan-cancer cohorts, NR0B2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NR0B2 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NR0B2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NR0B2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, SCLC, and CHOL are the cancer types where NR0B2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.178	0.743	.004	18	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUAD	DFS	Median	All	0.213	0.676	.024	3	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NR0B2–LUSC (OS)

Open the LUSC breakdown →